I believe it locks certain runes in as soon as you pick any corresponding Rune card and updates the draft choices accordingly (e.g. if you pick a triple Blood card you are locked into triple Blood and would only get no-rune and Blood rune cards; double Blood card locks two Blood runes and lets you pick up any third Rune later, and so on)
The overall situation is broken beyond belief regardless, though.
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I believe it locks certain runes in as soon as you pick any corresponding Rune card and updates the draft choices accordingly (e.g. if you pick a triple Blood card you are locked into triple Blood and would only get no-rune and Blood rune cards; double Blood card locks two Blood runes and lets you pick up any third Rune later, and so on)
The overall situation is broken beyond belief regardless, though.